NanoFlash / EIC Pathfinder Open 2026

Light-responsive nanostructures for vision restoration.

Research to develop a cell-targeted, gene-free route to reactivate natural retinal processing.
Explore the science Why NanoFlash

The challenge

The signal chain within the eye is interrupted.

In Retinitis Pigmentosa and atrophic Age-related Macular Degeneration, the loss of photoreceptors disrupts the retina’s natural ON/OFF pathways, preventing light from being translated into functional vision.
A gloved researcher uses a pipette to prepare a laboratory sample.

NanoFlash

Reconnect the retina’s natural response to light.

Soft, light-sensitive nanoactuators are designed to selectively target mGluR6 receptors on rod and cone ON bipolar cells. By activating these surviving cells with light, NanoFlash aims to restore the retina’s natural ON/OFF signalling, but without modifying their genes.

See how the technology works

Why it matters

Use the retina's remaining visual network.

Precise

Target specific cells rather than stimulating the entire network.

Gene-free

Explore restoring light responses without changing a person's genes.

Functional

Study whether the retina can recover contrast, detail and colour perception.

Stepwise

Build evidence carefully, from simple models to more complex ones.
Two researchers discuss scientific work beside a computer.

About NanoFlash

From smart design to biological testing.

NanoFlash brings together expertise in materials, chemistry, photophysics, neuroscience and engineering to develop and test a new approach to vision restoration.

Testing progresses step by step, from cells and human retinal organoids to retinal tissue and animal studies.

Latest news

Follow the latest research, collaborations and milestones from the NanoFlash research programme.

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